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Power in Voxel-based Lesion–Symptom Mapping

¹ University of Pennsylvania, ² Moss Rehabilitation Research Institute, Philadelphia, PA

Reprint requests should be sent to Daniel Y. Kimberg, Department of Neurology, 3W Gates, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, or via e-mail: kimberg{at}mail.med.upenn.edu; Web: www.voxbo.org, http://cfn.upenn.edu.

Lesion analysis in brain-injured populations complements what can be learned from functional neuroimaging. Voxel-based approaches to mapping lesion–behavior correlations in brain-injured populations are increasingly popular, and have the potential to leverage image analysis methods drawn from functional magnetic resonance imaging. However, power is a major concern for these studies, and is likely to vary regionally due to the distribution of lesion locations. Here, we outline general considerations for voxel-based methods, characterize the use of a nonparametric permutation test adapted from functional neuroimaging, and present methods for regional power analysis in lesion studies.

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