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Local Field Potentials and Spikes in the Human Medial Temporal Lobe are Selective to Image Category

¹ California Institute of Technology, ² University of Leicester, UK, ³ Massachusetts Institute of Technology, ⁴ University of California at Los Angeles, ⁵ Tel-Aviv University, Israel

Reprint requests should be sent to Dr. Alexander Kraskov, Sobell Department of Motor Neuroscience, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK, or via e-mail: a.kraskov{at}ion.ucl.ac.uk.

Local field potentials (LFPs) reflect the averaged dendrosomatic activity of synaptic signals of large neuronal populations. In this study, we investigate the selectivity of LFPs and single neuron activity to semantic categories of visual stimuli in the medial temporal lobe of nine neurosurgical patients implanted with intracranial depth electrodes for clinical reasons. Strong selectivity to the category of presented images was found for the amplitude of LFPs in 8% of implanted microelectrodes and for the firing rates of single and multiunits in 14% of microelectrodes. There was little overlap between the LFP- and spike-selective microelectrodes. Separate analysis of the power and phase of LFPs revealed that the mean phase was category-selective around the frequency range and that the power of the LFPs was category-selective for high frequencies around the rhythm. Of the 36 microelectrodes with amplitude-selective LFPs, 30 were found in the hippocampus. Finally, it was possible to readout information about the category of stimuli presented to the patients with both spikes and LFPs. Combining spiking and LFP activity enhanced the decoding accuracy in comparison with the accuracy obtained with each signal alone, especially for short time intervals.

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