| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 University College London, UK, 2 University of Aberdeen, UK, 3 University of Edinburgh, UK
Reprint requests should be sent to Sam Gilbert, Institute of Cognitive Neuroscience, 17 Queen Square, London WC1N 3AR, UK, or via e-mail: sam.gilbert{at}ucl.ac.uk.
One of the least well understood regions of the human brain is rostral prefrontal cortex, approximating Brodmann's area 10. Here, we investigate the possibility that there are functional subdivisions within this region by conducting a meta-analysis of 104 functional neuroimaging studies (using positron emission tomography/functional magnetic resonance imaging). Studies involving working memory and episodic memory retrieval were disproportionately associated with lateral activations, whereas studies involving mentalizing (i.e., attending to one's own emotions and mental states or those of other agents) were disproportionately associated with medial activations. Functional variation was also observed along a rostral–caudal axis, with studies involving mentalizing yielding relatively caudal activations and studies involving multiple-task coordination yielding relatively rostral activations. A classification algorithm was trained to predict the task, given the coordinates of each activation peak. Performance was well above chance levels (74% for the three most common tasks; 45% across all eight tasks investigated) and generalized to data not included in the training set. These results point to considerable functional segregation within rostral prefrontal cortex.
This article has been cited by other articles:
|
|
 |
|
  A. Abraham, D. Y. von Cramon, and R. I. Schubotz Meeting George Bush versus Meeting Cinderella: The Neural Response When Telling Apart What is Real from What is Fictional in the Context of Our Reality. J. Cogn. Neurosci., June 1, 2008; 20(6): 965 - 976. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Vinogradov, T. L. Luks, B. J. Schulman, and G. V. Simpson Deficit in a Neural Correlate of Reality Monitoring in Schizophrenia Patients Cereb Cortex, May 23, 2008; (2008) bhn028v3. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Wendelken, D. Nakhabenko, S. E. Donohue, C. S. Carter, and S. A. Bunge "Brain is to thought as stomach is to ??": investigating the role of rostrolateral prefrontal cortex in relational reasoning. J. Cogn. Neurosci., April 1, 2008; 20(4): 682 - 693. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Simons, R. N. A. Henson, S. J. Gilbert, and P. C. Fletcher Separable forms of reality monitoring supported by anterior prefrontal cortex. J. Cogn. Neurosci., March 1, 2008; 20(3): 447 - 457. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Raboyeau, X. De Boissezon, N. Marie, S. Balduyck, M. Puel, C. Bezy, J. F. Demonet, and D. Cardebat Right hemisphere activation in recovery from aphasia: Lesion effect or function recruitment? Neurology, January 22, 2008; 70(4): 290 - 298. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Badre and M. D'Esposito Functional magnetic resonance imaging evidence for a hierarchical organization of the prefrontal cortex. J. Cogn. Neurosci., December 1, 2007; 19(12): 2082 - 2099. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Koechlin and A. Hyafil Anterior Prefrontal Function and the Limits of Human Decision-Making Science, October 26, 2007; 318(5850): 594 - 598. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Petrides and D. N. Pandya Efferent Association Pathways from the Rostral Prefrontal Cortex in the Macaque Monkey J. Neurosci., October 24, 2007; 27(43): 11573 - 11586. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Krueger, J. Moll, R. Zahn, A. Heinecke, and J. Grafman Event Frequency Modulates the Processing of Daily Life Activities in Human Medial Prefrontal Cortex Cereb Cortex, October 1, 2007; 17(10): 2346 - 2353. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. Gilbert, I. D. M. Williamson, I. Dumontheil, J. S. Simons, C. D. Frith, and P. W. Burgess Distinct regions of medial rostral prefrontal cortex supporting social and nonsocial functions Soc Cogn Affect Neurosci, September 1, 2007; 2(3): 217 - 226. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Gilbert, I. Dumontheil, J. S. Simons, C. D. Frith, and P. W. Burgess Comment on "Wandering Minds: The Default Network and Stimulus-Independent Thought" Science, July 6, 2007; 317(5834): 43b - 43b. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. U. F. Dosenbach, D. A. Fair, F. M. Miezin, A. L. Cohen, K. K. Wenger, R. A. T. Dosenbach, M. D. Fox, A. Z. Snyder, J. L. Vincent, M. E. Raichle, et al. Distinct brain networks for adaptive and stable task control in humans PNAS, June 26, 2007; 104(26): 11073 - 11078. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Wraga, M. Helt, E. Jacobs, and K. Sullivan Neural basis of stereotype-induced shifts in women's mental rotation performance Soc Cogn Affect Neurosci, March 1, 2007; 2(1): 12 - 19. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| NEURAL COMPUTATION | J COGNITIVE NEUROSCIENCE | MIT PRESS JOURNALS |
