HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Chee, M. W. L. Articles by Park, D. Search for Related Content PubMed Articles by Chee, M. W. L. Articles by Park, D.

Age-related Changes in Object Processing and Contextual Binding Revealed Using fMR Adaptation

¹ SingHealth, Singapore, ² University of Illinois

Reprint requests should be sent to Michael W. L. Chee, Cognitive Neuroscience Laboratory, 7 Hospital Drive, #01-11, Singapore 169611, Singapore, or via e-mail: mchee@pacific.net.sg.

Using fMR adaptation, we studied the effects of aging on the neural processing of passively viewed naturalistic pictures composed of a prominent object against a background scene. Spatially distinct neural regions showing specific patterns of adaptation to objects, background scenes, and contextual integration (binding) were identified in young adults. Older adults did not show adaptation responses corresponding to binding in the medial-temporal areas. They also showed an adaptation deficit for objects whereby their lateral occipital complex (LOC) did not adapt to repeated objects in the context of a changing background. The LOC could be activated, however, when objects were presented without a background. Moreover, the adaptation deficit for objects viewed against backgrounds was reversed when elderly subjects were asked to attend to objects while viewing these complex pictures. These findings suggest that the elderly have difficulty with simultaneous processing of objects and backgrounds that, in turn, could contribute to deficient contextual binding.

This article has been cited by other articles:

				C. L. GRADY Cognitive Neuroscience of Aging Ann. N.Y. Acad. Sci., March 1, 2008; 1124(1): 127 - 144. [Abstract] [Full Text] [PDF]

				C. L. Grady, H. Yu, and C. Alain Age-Related Differences in Brain Activity Underlying Working Memory for Spatial and Nonspatial Auditory Information Cereb Cortex, January 1, 2008; 18(1): 189 - 199. [Abstract] [Full Text] [PDF]

				A. M. Morcom, J. Li, and M. D. Rugg Age Effects on the Neural Correlates of Episodic Retrieval: Increased Cortical Recruitment with Matched Performance Cereb Cortex, November 1, 2007; 17(11): 2491 - 2506. [Abstract] [Full Text] [PDF]