HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ashby, F. G. Articles by Casale, M. B. Search for Related Content PubMed PubMed Citation Articles by Ashby, F. G. Articles by Casale, M. B.

FROST: A Distributed Neurocomputational Model of Working Memory Maintenance

¹ University of California, Santa Barbara, ² University of California, Berkeley

Reprint requests should be sent to F. Gregory Ashby, Department of Psychology, University of California, Santa Barbara, CA 93106, or via e-mail: ashby{at}psych.ucsb.edu.

Many studies suggest that the sustained activation underlying working memory (WM) maintenance is mediated by a distributed network that includes the prefrontal cortex and other structures (e.g., posterior parietal cortex, thalamus, globus pallidus, and the caudate nucleus). A computational model of WM, called FROST (short for FROntal–Striatal–Thalamic), is proposed in which the representation of items and spatial positions is encoded in the lateral prefrontal cortex. During delay intervals, activation in these prefrontal cells is sustained via parallel, prefrontal cortical–thalamic loops. Activation reverberates in these loops because prefrontal cortical excitation of the head of the caudate nucleus leads to disinhibition of the thalamus (via the globus pallidus). FROST successfully accounts for a wide variety of WM data, including single-cell recording data and human behavioral data.

This article has been cited by other articles:

				S. M. Landau, R. Lal, J. P. O'Neil, S. Baker, and W. J. Jagust Striatal Dopamine and Working Memory Cereb Cortex, June 11, 2008; (2008) bhn095v1. [Abstract] [Full Text] [PDF]

				H. Burianova and C. L. Grady Common and unique neural activations in autobiographical, episodic, and semantic retrieval. J. Cogn. Neurosci., September 1, 2007; 19(9): 1520 - 1534. [Abstract] [Full Text] [PDF]