| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Karolinska Institute, Astrid Lindgren Children's Hospital
In the human brain, myelination of axons continues until early adulthood and is thought to be important for the development of cognitive functions during childhood. We used diffusion tensor MR imaging and calculated fractional anisotropy, an indicator of myelination and axonal thickness, in children aged between 8 and 18 years. Development of working memory capacity was positively correlated with fractional anisotropy in two regions in the left frontal lobe, including a region between the superior frontal and parietal cortices. Reading ability, on the other hand, was only correlated with fractional anisotropy in the left temporal lobe, in the same white matter region where adults with reading disability are known to have lower fractional anisotropy. Both the temporal and the frontal regions were also correlated with age. These results show that maturation of white matter is an important part of brain maturation during childhood, and that maturation of relatively restricted regions of white matter is correlated with development of specific cognitive functions.
This article has been cited by other articles:
|
|
 |
|
  S. J. Counsell, A. D. Edwards, A. T. M. Chew, M. Anjari, L. E. Dyet, L. Srinivasan, J. P. Boardman, J. M. Allsop, J. V. Hajnal, M. A. Rutherford, et al. Specific relations between neurodevelopmental abilities and white matter microstructure in children born preterm Brain, October 24, 2008; (2008) awn268v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A.M. C. Kelly, A. Di Martino, L. Q. Uddin, Z. Shehzad, D. G. Gee, P. T. Reiss, D. S. Margulies, F. X. Castellanos, and M. P. Milham Development of Anterior Cingulate Functional Connectivity from Late Childhood to Early Adulthood Cereb Cortex, August 26, 2008; (2008) bhn117v2. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.N. Niogi, P. Mukherjee, J. Ghajar, C. Johnson, R.A. Kolster, R. Sarkar, H. Lee, M. Meeker, R.D. Zimmerman, G.T. Manley, et al. Extent of Microstructural White Matter Injury in Postconcussive Syndrome Correlates with Impaired Cognitive Reaction Time: A 3T Diffusion Tensor Imaging Study of Mild Traumatic Brain Injury AJNR Am. J. Neuroradiol., May 1, 2008; 29(5): 967 - 973. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Dubois, G. Dehaene-Lambertz, C. Soares, Y. Cointepas, D. Le Bihan, and L. Hertz-Pannier Microstructural Correlates of Infant Functional Development: Example of the Visual Pathways J. Neurosci., February 20, 2008; 28(8): 1943 - 1948. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. Eluvathingal, K. M. Hasan, L. Kramer, J. M. Fletcher, and L. Ewing-Cobbs Quantitative Diffusion Tensor Tractography of Association and Projection Fibers in Normally Developing Children and Adolescents Cereb Cortex, December 1, 2007; 17(12): 2760 - 2768. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B.J. Casey, J. N. Epstein, J. Buhle, C. Liston, M. C. Davidson, S. T. Tonev, J. Spicer, S. Niogi, A. J. Millner, A. Reiss, et al. Frontostriatal Connectivity and Its Role in Cognitive Control in Parent-Child Dyads With ADHD Am J Psychiatry, November 1, 2007; 164(11): 1729 - 1736. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Hoeft, N. Barnea-Goraly, B. W. Haas, G. Golarai, D. Ng, D. Mills, J. Korenberg, U. Bellugi, A. Galaburda, and A. L. Reiss More Is Not Always Better: Increased Fractional Anisotropy of Superior Longitudinal Fasciculus Associated with Poor Visuospatial Abilities in Williams Syndrome J. Neurosci., October 31, 2007; 27(44): 11960 - 11965. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Edin, J. Macoveanu, P. Olesen, J. Tegner, and T. Klingberg Stronger Synaptic Connectivity as a Mechanism behind Development of Working Memory-related Brain Activity during Childhood. J. Cogn. Neurosci., May 1, 2007; 19(5): 750 - 760. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Olesen, J. Macoveanu, J. Tegner, and T. Klingberg Brain Activity Related to Working Memory and Distraction in Children and Adults Cereb Cortex, May 1, 2007; 17(5): 1047 - 1054. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Skranes, T. R. Vangberg, S. Kulseng, M. S. Indredavik, K. A. I. Evensen, M. Martinussen, A. M. Dale, O. Haraldseth, and A.-M. Brubakk Clinical findings and white matter abnormalities seen on diffusion tensor imaging in adolescents with very low birth weight Brain, March 1, 2007; 130(3): 654 - 666. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. VAN AMELSVOORT, N. SCHMITZ, E. DALY, Q. DEELEY, H. CRITCHLEY, J. HENRY, D. ROBERTSON, M. OWEN, K. C. MURPHY, and D. G. MURPHY Processing facial emotions in adults with velo-cardio-facial syndrome: functional magnetic resonance imaging The British Journal of Psychiatry, December 1, 2006; 189(6): 560 - 561. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Lieberman, R. Lyon, J. Feiner, M. Diab, and G. A. Gregory The effect of age on motor evoked potentials in children under propofol/isoflurane anesthesia. Anesth. Analg., August 1, 2006; 103(2): 316 - 21, table of contents. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Liston, R. Watts, N. Tottenham, M. C. Davidson, S. Niogi, A. M. Ulug, and B.J. Casey Frontostriatal Microstructure Modulates Efficient Recruitment of Cognitive Control Cereb Cortex, April 1, 2006; 16(4): 553 - 560. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P.-L. Khong, L. H.T. Leung, A. S.M. Fung, D. Y.T. Fong, D. Qiu, D. L.W. Kwong, G.-C. Ooi, G. McAlanon, G. Cao, and G. C.F. Chan White Matter Anisotropy in Post-Treatment Childhood Cancer Survivors: Preliminary Evidence of Association With Neurocognitive Function J. Clin. Oncol., February 20, 2006; 24(6): 884 - 890. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| NEURAL COMPUTATION | J COGNITIVE NEUROSCIENCE | MIT PRESS JOURNALS |
