| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Medical College of Wisconsin
West Virginia University
University of Alberta
Medical College of Wisconsin
University of Windsor
People can discriminate real words from nonwords even when the latter are orthographically and phonologically word-like, presumably because words activate specific lexical and/or semantic information. We investigated the neural correlates of this identification process using event-related functional magnetic resonance imaging (fMRI). Participants performed a visual lexical decision task under conditions that encouraged specific word identification: Nonwords were matched to words on orthographic and phonologic characteristics, and accuracy was emphasized over speed. To identify neural responses associated with activation of nonsemantic lexical information, processing of words and nonwords with many lexical neighbors was contrasted with processing of items with no neighbors. The fMRI data showed robust differences in activation by words and word-like nonwords, with stronger word activation occurring in a distributed, left hemisphere network previously associated with semantic processing, and stronger nonword activation occurring in a posterior inferior frontal area previously associated with grapheme-to-phoneme mapping. Contrary to lexicon-based models of word recognition, there were no brain areas in which activation increased with neighborhood size. For words, activation in the left prefrontal, angular gyrus, and ventrolateral temporal areas was stronger for items without neighbors, probably because accurate responses to these items were more dependent on activation of semantic information. The results show neural correlates of access to specific word information. The absence of facilitatory lexical neighborhood effects on activation in these brain regions argues for an interpretation in terms of semantic access. Because subjects performed the same task throughout, the results are unlikely to be due to task-specific attentional, strategic, or expectancy effects.
This article has been cited by other articles:
|
|
 |
|
  N. Ihssen, S. Heim, and A. Keil The Costs of Emotional Attention: Affective Processing Inhibits Subsequent Lexico-semantic Analysis. J. Cogn. Neurosci., December 1, 2007; 19(12): 1932 - 1949. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kronbichler, J. Bergmann, F. Hutzler, W. Staffen, A. Mair, G. Ladurner, and H. Wimmer Taxi vs. taksi: on orthographic word recognition in the left ventral occipitotemporal cortex. J. Cogn. Neurosci., October 1, 2007; 19(10): 1584 - 1594. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. T. Wehner, S. P. Ahlfors, and M. Mody The Influence of Semantic Processing on Phonological Decisions in Children and Adults: A Magnetoencephalography (MEG) Study J Speech Lang Hear Res, June 1, 2007; 50(3): 716 - 731. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. W. Graves, T. J. Grabowski, S. Mehta, and J. K. Gordon A neural signature of phonological access: distinguishing the effects of word frequency from familiarity and length in overt picture naming. J. Cogn. Neurosci., April 1, 2007; 19(4): 617 - 631. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Carreiras, A. Mechelli, A. Estevez, and C. J. Price Brain activation for lexical decision and reading aloud: two sides of the same coin? J. Cogn. Neurosci., March 1, 2007; 19(3): 433 - 444. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Obleser, R. J. S. Wise, M. Alex Dresner, and S. K. Scott Functional Integration across Brain Regions Improves Speech Perception under Adverse Listening Conditions J. Neurosci., February 28, 2007; 27(9): 2283 - 2289. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Spitsyna, J. E. Warren, S. K. Scott, F. E. Turkheimer, and R. J. S. Wise Converging language streams in the human temporal lobe. J. Neurosci., July 12, 2006; 26(28): 7328 - 7336. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Hauk, K. Patterson, A. Woollams, L. Watling, F. Pulvermuller, and T. T. Rogers [Q:] When would you prefer a SOSSAGE to a SAUSAGE? [A:] At about 100 msec. ERP correlates of orthographic typicality and lexicality in written word recognition. J. Cogn. Neurosci., May 1, 2006; 18(5): 818 - 832. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Humphries, J. R. Binder, D. A. Medler, and E. Liebenthal Syntactic and semantic modulation of neural activity during auditory sentence comprehension. J. Cogn. Neurosci., April 1, 2006; 18(4): 665 - 679. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. A. Kirchhoff, M. L. Schapiro, and R. L. Buckner Orthographic Distinctiveness and Semantic Elaboration Provide Separate Contributions to Memory J. Cogn. Neurosci., December 1, 2005; 17(12): 1841 - 1854. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. Kable, I. P. Kan, A. Wilson, S. L. Thompson-Schill, and A. Chatterjee Conceptual Representations of Action in the Lateral Temporal Cortex J. Cogn. Neurosci., December 1, 2005; 17(12): 1855 - 1870. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Mechelli, J. T. Crinion, S. Long, K. J. Friston, M. A. Lambon Ralph, K. Patterson, J. L. McClelland, and C. J. Price Dissociating Reading Processes on the Basis of Neuronal Interactions J. Cogn. Neurosci., November 1, 2005; 17(11): 1753 - 1765. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Binder, C. F. Westbury, K. A. McKiernan, E. T. Possing, and D. A. Medler Distinct Brain Systems for Processing Concrete and Abstract Concepts J. Cogn. Neurosci., June 1, 2005; 17(6): 905 - 917. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. W. Lewis, F. L. Wightman, J. A. Brefczynski, R. E. Phinney, J. R. Binder, and E. A. DeYoe Human Brain Regions Involved in Recognizing Environmental Sounds Cereb Cortex, September 1, 2004; 14(9): 1008 - 1021. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ischebeck, P. Indefrey, N. Usui, I. Nose, F. Hellwig, and M. Taira Reading in a Regular Orthography: An fMRI Study Investigating the Role of Visual Familiarity J. Cogn. Neurosci., June 1, 2004; 16(5): 727 - 741. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| NEURAL COMPUTATION | J COGNITIVE NEUROSCIENCE | MIT PRESS JOURNALS |
