J. Cogn. Neurosci.
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(Journal of Cognitive Neuroscience. 2002;14:673-686.)
© 2002 The MIT Press

Contributions of Subregions of the Prefrontal Cortex to Working Memory: Evidence from Brain Lesions in Humans

Notger G. Müller

University of Frankfurt
University of California at Berkeley and the Helen Wills Neuroscience Institute
Veterans Administration Medical Center, Martinez, CA, USA

Liana Machado

University of Wales
Veterans Administration Medical Center, Martinez, CA, USA

Robert T. Knight

University of California at Berkeley and the Helen Wills Neuroscience Institute
Veterans Administration Medical Center, Martinez, CA, USA

We investigated working memory in patients with focal brain damage involving subregions of the prefrontal cortex (PFC). Lesions in the dorsal portion of lateral PFC or the ventromedial portion of orbital PFC did not impair performance in tasks that required maintenance and monitoring of object or spatial information. Larger lesions involving both ventral and dorsal parts of the lateral PFC impaired maintenance and monitoring of spatial and object information, with more severe deficits observed in the spatial tasks. The results support a distributed localization of function in lateral PFC during working memory.




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