HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Simons, J. S. Articles by Hodges, J. R. Search for Related Content PubMed PubMed Citation Articles by Simons, J. S. Articles by Hodges, J. R.

Perceptual and Semantic Components of Memory for Objects and Faces: A PET Study

MRC Cognition and Brain Sciences Unit, Cambridge, UK

Adrian M. Owen

MRC Cognition and Brain Sciences Unit, Cambridge, UK
Wolfson Brain Imaging Centre, Addenbrooke's Hospital, Cambridge, UK

Karalyn Patterson

MRC Cognition and Brain Sciences Unit, Cambridge, UK

John R. Hodges

MRC Cognition and Brain Sciences Unit, Cambridge, UK
University Neurology Unit, Addenbrooke's Hospital, Cambridge, UK

Previous studies have suggested differences in the neural substrates of recognition memory when the contributions of perceptual and semantic information are manipulated. In a within-subjects design PET study, we investigated the neural correlates of the following factors: material type (objects or faces), semantic knowledge (familiar or unfamiliar items), and perceptual similarity at study and test (identical or different pictures). There was consistent material-specific lateralization in frontal and temporal lobe regions when the retrieval of different types of nonverbal stimuli was compared, with objects activating bilateral areas and faces preferentially activating the right hemisphere. Retrieval of memories for nameable, familiar items was associated with increased activation in the left ventrolateral prefrontal cortex, while memory for unfamiliar items involved occipital regions. Recognition memory for different pictures of the same item at study and test produced blood flow increase in left inferior temporal cortex. These results have implications for our understanding of the neural correlates of perceptual and semantic contributions to recognition memory.

This article has been cited by other articles:

				M. N. Rajah and A. R. McIntosh Overlap in the Functional Neural Systems Involved in Semantic and Episodic Memory Retrieval J. Cogn. Neurosci., March 1, 2005; 17(3): 470 - 482. [Abstract] [Full Text] [PDF]

				S. E. Prince, S. M. Daselaar, and R. Cabeza Neural Correlates of Relational Memory: Successful Encoding and Retrieval of Semantic and Perceptual Associations J. Neurosci., February 2, 2005; 25(5): 1203 - 1210. [Abstract] [Full Text] [PDF]

				M. Sugiura, N. J. Shah, K. Zilles, and G. R. Fink Cortical Representations of Personally Familiar Objects and Places: Functional Organization of the Human Posterior Cingulate Cortex J. Cogn. Neurosci., February 1, 2005; 17(2): 183 - 198. [Abstract] [Full Text] [PDF]

				S. G. Coleshill, C. D. Binnie, R. G. Morris, G. Alarcon, W. van Emde Boas, D. N. Velis, A. Simmons, C. E. Polkey, C. W. M. van Veelen, and P. C. van Rijen Material-Specific Recognition Memory Deficits Elicited by Unilateral Hippocampal Electrical Stimulation J. Neurosci., February 18, 2004; 24(7): 1612 - 1616. [Abstract] [Full Text] [PDF]

				M. L. Kellenbach, M. Brett, and K. Patterson Actions Speak Louder Than Functions: The Importance of Manipulability and Action in Tool Representation J. Cogn. Neurosci., January 1, 2003; 15(1): 30 - 46. [Abstract] [Full Text] [PDF]