J. Cogn. Neurosci.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cabeza, R.
Right arrow Articles by Houle, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cabeza, R.
Right arrow Articles by Houle, S.
(Journal of Cognitive Neuroscience. 2000;12:197-206.)
© 2000 The MIT Press

Articles

Age-Related Differences in Neural Activity during Item and Temporal-Order Memory Retrieval: A Positron Emission Tomography Study

Roberto Cabezaa, Nicole D. Andersonb, Jennifer A. Mangelsc, Lars Nybergd and Sylvain Houleb

a University of Alberta
b University of Toronto
c Columbia University
d University of Ume

Corresponding author. Department of Psychology, University of Alberta, P220 Biological Sciences Bldg., Edmonton, ALTA, Canada T6G 2E9. Tel.: +1-403-492-7778; fax: +1-403-492-1768; cabeza{at}psych.ualberta.ca

Positron emission tomography (PET) was used to investigate the hypothesis that older adults' difficulties with temporal-order memory are related to deficits in frontal function. Young (mean 24.7 years) and old (mean 68.6 years) participants studied a list of words, and were then scanned while retrieving information about what words were in the list (item retrieval) or when they occurred within the list (temporal-order retrieval). There were three main results. First, whereas the younger adults engaged right prefrontal regions more during temporal-order retrieval than during item retrieval, the older adults did not. This result is consistent with the hypothesis that context memory deficits in older adults are due to frontal dysfunction. Second, ventromedial temporal activity during item memory was relatively unaffected by aging. This finding concurs with evidence that item memory is relatively preserved in old adults and with the notion that medial temporal regions are involved in automatic retrieval operations. Finally, replicating the result of a previous study (Cabeza, R., Grady, C. L., Nyberg, L., McIntosh, A. R., Tulving, E., Kapur, S., Jennings, J. M., Houle, S., & Craik, F. I. M., 1997), the old adults showed weaker activations than the young adults in the right prefrontal cortex but stronger activations in the left prefrontal cortex. The age-related increase in left prefrontal activity may be interpreted as compensatory. Taken together, the results suggest that age-related changes in brain activity are rather process- and region-specific, and that they involve increases as well as decreases in neural activity.


Key Words: Cerebral bloodflow • Aging • Retrieval • Recognition • Recency • Frontal lobes • Medial temporal lobes • Reorganization • Compensation




This article has been cited by other articles:


Home page
 J. Neurosci.Home page
T. Jubault, C. Ody, and E. Koechlin
Serial Organization of Human Behavior in the Inferior Parietal Cortex
J. Neurosci., October 10, 2007; 27(41): 11028 - 11036.
[Abstract] [Full Text] [PDF]

Home page
 J. Gerontol. B Psychol. Sci. Soc. Sci.Home page
P. Allain, G. Berrut, F. Etcharry-Bouyx, J. Barre, F. Dubas, and D. L. Gall
Executive Functions in Normal Aging: An Examination of Script Sequencing, Script Sorting, and Script Monitoring
J. Gerontol. B. Psychol. Sci. Soc. Sci., May 1, 2007; 62(3): P187 - P190.
[Abstract] [Full Text] [PDF]

Home page
 J Geriatr Psychiatry NeurolHome page
L. Minati, M. Grisoli, and M. G. Bruzzone
MR Spectroscopy, Functional MRI, and Diffusion-Tensor Imaging in the Aging Brain: A Conceptual Review
J Geriatr Psychiatry Neurol, March 1, 2007; 20(1): 3 - 21.
[Abstract] [PDF]

Home page
 Cereb CortexHome page
S. M. Daselaar, M. S. Fleck, I. G. Dobbins, D. J. Madden, and R. Cabeza
Effects of Healthy Aging on Hippocampal and Rhinal Memory Functions: An Event-Related fMRI Study
Cereb Cortex, December 1, 2006; 16(12): 1771 - 1782.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
M. Cotelli, R. Manenti, S. F. Cappa, C. Geroldi, O. Zanetti, P. M. Rossini, and C. Miniussi
Effect of Transcranial Magnetic Stimulation on Action Naming in Patients With Alzheimer Disease
Arch Neurol, November 1, 2006; 63(11): 1602 - 1604.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
S. Konishi, T. Asari, K. Jimura, J. Chikazoe, and Y. Miyashita
Activation Shift from Medial to Lateral Temporal Cortex Associated with Recency Judgements Following Impoverished Encoding
Cereb Cortex, April 1, 2006; 16(4): 469 - 474.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
J. J. Foxe, M. M. Murray, and D. C. Javitt
Filling-in in Schizophrenia: a High-density Electrical Mapping and Source-analysis Investigation of Illusory Contour Processing
Cereb Cortex, December 1, 2005; 15(12): 1914 - 1927.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
M. N. Rajah and M. D'Esposito
Region-specific changes in prefrontal function with age: a review of PET and fMRI studies on working and episodic memory
Brain, September 1, 2005; 128(9): 1964 - 1983.
[Abstract] [Full Text] [PDF]

Home page
 Neural Comput.Home page
C. Habeck, J. W. Krakauer, C. Ghez, H. A. Sackeim, D. Eidelberg, Y. Stern, and J. R. Moeller
A New Approach to Spatial Covariance Modeling of Functional Brain Imaging Data: Ordinal Trend Analysis
Neural Comput., July 1, 2005; 17(7): 1602 - 1645.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. Rossi, C. Miniussi, P. Pasqualetti, C. Babiloni, P. M. Rossini, and S. F. Cappa
Age-Related Functional Changes of Prefrontal Cortex in Long-Term Memory: A Repetitive Transcranial Magnetic Stimulation Study
J. Neurosci., September 8, 2004; 24(36): 7939 - 7944.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
R A Sperling, J F Bates, E F Chua, A J Cocchiarella, D M Rentz, B R Rosen, D L Schacter, and M S Albert
fMRI studies of associative encoding in young and elderly controls and mild Alzheimer's disease
J. Neurol. Neurosurg. Psychiatry, January 1, 2003; 74(1): 44 - 50.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. Konishi, I. Uchida, T. Okuaki, T. Machida, I. Shirouzu, and Y. Miyashita
Neural Correlates of Recency Judgment
J. Neurosci., November 1, 2002; 22(21): 9549 - 9555.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
T. Darreh-Shori, O. Almkvist, Z. Z. Guan, A. Garlind, B. Strandberg, A.-L. Svensson, H. Soreq, E. Hellstrom-Lindahl, and A. Nordberg
Sustained cholinesterase inhibition in AD patients receiving rivastigmine for 12 months
Neurology, August 27, 2002; 59(4): 563 - 572.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
D. H. Salat, J. A. Kaye, and J. S. Janowsky
Greater Orbital Prefrontal Volume Selectively Predicts Worse Working Memory Performance in Older Adults
Cereb Cortex, May 1, 2002; 12(5): 494 - 505.
[Abstract] [Full Text] [PDF]

Home page
 Learn. Mem.Home page
G. Gron, D. Bittner, B. Schmitz, A. P. Wunderlich, R. Tomczak, and M. W. Riepe
Hippocampal Activations during Repetitive Learning and Recall of Geometric Patterns
Learn. Mem., November 1, 2001; 8(6): 336 - 345.
[Abstract] [Full Text] [PDF]

Home page
 J. Cogn. Neurosci.Home page
C. Marshuetz, E. E. Smith, J. Jonides, J. DeGutis, and T. L. Chenevert
Order Information in Working Memory: fMRI Evidence for Parietal and Prefrontal Mechanisms
J. Cogn. Neurosci., November 1, 2000; 12(90002): 130S - 144.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
NEURAL COMPUTATION J COGNITIVE NEUROSCIENCE MIT PRESS JOURNALS
Copyright © 2000 by The MIT Press.