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The Journal of Cognitive Neuroscience, Vol 10, 316-331, Copyright © 1998 by The MIT Press

ARTICLES

Coupled Temporal Memories in Parkinson's Disease: A Dopamine-Related Dysfunction

Chara Malapani, Brian Rakitin, Warren H. Meck, Bernard Deweer, Bruno Dubois and John Gibbon

Dysfunction of the basal ganglia and the brain nuclei interconnected with them leads to disturbances of movement and cognition, including disordered timing of movement and perceptual timing deficits. Patients with Parkinson's disease (PD) were studied in temporal reproduction tasks. We examined PD patients when brain dopamine (DA) transmission was impaired (OFF state) and when DA transmission was reestablished, at the time of maximal clinical benefit following administration of levodopa apomorphine (ON state). Patients reproduced target times of 8 and 21 sec trained in blocked trials with the peak interval procedure, which were veridical in the ON state, comparable to normative performance by healthy young and aged controls (Experiment 1). In the OFF state, temporal reproduction was impaired in both accuracy and precision (variance). The 8-sec signal was reproduced as longer and the 21-sec signal


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NEURAL COMPUTATION J COGNITIVE NEUROSCIENCE MIT PRESS JOURNALS
Copyright © 1998 by The MIT Press.